Innate Immunity |
Refers to non-specific defense mechanisms that come into play immediately or within house of an antigen’s appearance in the body. It is ALREADY PRESENT in body. Composed of chemical and mechnical barriers , phagocytes, and chemical mediators.
Does not include: specific B and T cells |
Adaptive Immunity |
Form of long-term acquired immunity. Created in response to exposure to a foreign substance. Usually specific and slow (1-2 weeks)
HIGH Potency and is not passed from parents to offspring. It develops during a person’s lifetime ,usually in lymph nodes, spleen, mucosal associated lymphoid tissue. {{nl}] Compsed of B and T cells |
Cytokines |
A peptide factor released by cells to influence the behavior of target cells. They have signaling inflammatory, growth, and inhibitory fucntions |
Histamines |
A compound found in cells; especially in mast cells
it is produced by the breakdown of histidine (an amino acid). It is released in allergic inflammatory reaction. Dilates blood vessels. Part of body’s natural allergic response |
Prostaglandin |
Hormone like substance that effects smooth muscle , dilation and constriction of blood vessels, control of BP, modulation of inflammation, and platelet function. |
Prostaglandin |
Hormone like substance that effects smooth muscle , dilation and constriction of blood vessels, control of BP, modulation of inflammation, and platelet function. |
Bradykinins |
Compound released in blood that causes smooth muscle contraction and dilation of blood vessels. Peptide comprised of 9-aa residues. Formed locally in injured tissue. |
Autoimmunity |
An inappropriate and excessive response of the immune system to self antigens causing disease. Disorders that result from an autoimmune response are called autoimmune diseases. Misdirected immune repsonse, immune system attacks the body itself. |
Hypersensitivity type 1 |
Anaphylactic !
Immediate or IgE-mediated reaction.
anaphylaxis
15-30 mins |
Hypersensitivity type 2 |
Cytotoxic, Cytolytic: IgG/IgM mediated response and anti-body mediated cell stimulating. Surfacing Ag and Ab, leading to killer cell cytoxic action
15-30 min
ex: Graves’ disease |
Hypersensitivity type 3 |
Arthur’s Reaction !
IgG/IgM immune complex mediated response. Ag-Ab complex deposited in tissues.
6 hours or more. Caused by persistent infection—microbe antigen. |
Hypersensitivity type 4 |
Delayed Hypersensitivity.T cell mediated , with 4 major categories. CD4*Th1 or Th2. CD8+. Recruits macrophages, eosinophils, or neutrophils, which release cytokines. Takes 24-48 hours or more.
Caused by in either intradermal, epidermal, dermal antigens.
SJS, toxic epidermal necrolysis |
Secondary Immune Deficiency Syndrome |
Conditions that impair immune function as a result of other noimmune system disorders, such as poor nutrition, pregnancy, stress, or drugs, that secondarily suppress immune function. |
CBC |
Complete blood count. Blood test to evaluate overall health |
WBC |
White blood cell. A cell that mediates immune fucntion. These include granulocytes, monocytes, and lymphocytes. |
CMP |
Comprehensive Metabolic Panel. blood test that gives doctors information about the body's fluid balance, levels of electrolytes like sodium and potassium, and how well the kidneys and liver are working. |
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